The influence of some medicinal compounds on the rheological properties of aqueous solutions of pectin

Abstract

The article is devoted to the study of the rheological behavior of pectin solutions in the presence of medicinal compounds – the antibiotics amikacin and cefazolin. The need for this study is due to the fact that the conformational and supramolecular state of pectin belonging to the class of polyelectrolytes, in addition to temperature, the chemical nature of the polymer and solvent, is largely determined by factors such as the degree of binding of counterions by macroions, as well as the concentration of low molecular weight salts present in the solution. Since medicinal substances are quite often low molecular weight electrolytes, they can have a significant impact on the process of pectin structure formation in solution, and, consequently, on its rheological properties. It was found that the presence of low molecular weight electrolytes of the antibiotics amikacin and cefazolin causes the shielding of the charge on the macromolecular chain and contributes to the strengthening of intra and intermolecular interaction. This fact, in turn, leads to a number of changes in the rheological state of the polymer solution, which must be taken into account when forming biomedical materials based on pectin.